Pdi value in malvern zetasizer nano
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The size of the molecules can be used as a quality control measure.
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For example, proteins are being utilized directly in the pharmaceutical industry as active agents in drugs (Akagi et al. Measuring the size of small molecules is currently of great interest in many applications. Evidence to support these size results for sucrose is discussed. These sucrose results suggest that sub nanometer measurements are achievable with a precision of 0.1 nm.
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Pdi value in malvern zetasizer nano series#
The peak means (with standard deviations) obtained for the intensity and volume data from a series of sucrose concentrations, ranging from 5 to 35% w/v, were measured as D I,Mean = 0.82 nm (0.11 nm) and D V,Mean = 0.62 nm (0.05 nm), respectively. Hydrodynamic diameter values of less than 1 nm are obtained by the use of 173° backscatter detection that is applied to increase the sensitivity of DLS. This paper discusses the factors which will influence the lower size limit of DLS and reports the use of sucrose as a test sample to probe this lower limit of the technique. Diffusion coefficient and particle size information can be obtained from the analysis of these fluctuations. Dynamic light scattering (DLS) measures time-dependent fluctuations in the scattering intensity arising from particles undergoing random Brownian motion.